FUNCTIONALLY OVERLAPPING INTRA- AND EXTRALYSOSOMAL PATHWAYS PROMOTE BIS(MONOACYLGLYCERO)PHOSPHATE SYNTHESIS IN MAMMALIAN CELLS

Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells

Abstract Bis(monoacylglycero)phosphate (BMP) is a major phospholipid constituent of intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation and sorting of lipid cargo.Recent observations suggest that the Batten disease-associated protein CLN5 functions as lysosomal BMP synthase.Here, we show that transacylation reacti

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Numerical Simulation of Mixing Characteristics in the Eccentric Rotor Extruder with Different Process Conditions and Structural Parameters

Numerical simulation was performed with the computational fluid dynamics analysis software POLYFLOW to investigate the influence of different princess jasmine silhouette process conditions and structural parameters on mixing characteristics of the eccentric rotor extruder.The intensity of shear and elongational flow strengthened when the rotational

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